Specific approaches to the treatment of arterial hypertension in old age


aging, age-related changes, age-dependent pathologies, polymorbidity, geriatric syndromes, hypertension, antihypertensive therapy.

How to Cite

Yena , L., Artemenko , V., & Akhaladze , M. (2019). Specific approaches to the treatment of arterial hypertension in old age. The Journal of Neuroscience, 7(3-4), 17-23. Retrieved from https://neuroscience.com.ua/index.php/journal/article/view/135


Aging population, increasing life expectancy have turned to mankind with complex medical and social challenges. Elderly population is characterized by a distinct heterogeneity of health status, which is determined by the combination of age-related changes, age-dependent pathology, polymorbidity, geriatric syndromes. This greatly modifies the significance of risk factors, in particular blood pressure: in old persons both high and low its levels have the risk of unfavorable outcomes. The article discusses changes in the formulation of goals, objectives, tactics of antihypertensive therapy for elderly patients with hypertension, its features in the presence of some geriatric syndromes.



1. van den Bussche H., Daniela Koller D., Kolonko T. et al. Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results
of a claims data based cross-sectional study in Germany // BMC Public Health. — 2011. — 11. — Р. 101. Published online 2011 February 14; doi: 10.1186/1471-
2. Formiga F., Ferrer A., Sanz H. et al. on behalf of the Octabaix study members. Patterns of comorbidity and multimorbidity in the oldest old: The Octabaix study // Eur. J. Intern. Med. — 2013. — Vol. 24, N. 1. — P. 40-44.
3. Jyrkka J., Enlund H., Korhonen M. et al. Polypharmacy Status as an Indicator of Mortality in an Elderly Population // Drugs Aging. — 2009. — Vol. 26, N12. —
P. 1039-1048.
4. Shan B., Haijar E. Polypharmacy, Adverse Drug Reaction, And Geriatric Syndrome // Clin. Geriatr. Med. — 2012. — Vol. 1. (28). — P. 173-186.
5 Kang M.G., Kim S.W., Yoon S.J., Choi J.Y., Kim K.I., Kim C.H. Association between frailty and hypertension prevalence, treatment, and control in the elderly Korean
population // Sci. Rep. — 2017. — 7. — P. 7542.
6. Supiano M.A., Williamson J.D. Applying the systolic blood pressure intervention trial results to older adults // J. Am. Geriatr. Soc. — 2017. — 65. — P. 16-21.
7. Jung H.W., Kim K.I. Blood pressure variability and cognitive function in the elderly // Pulse (Basel). — 2013. — 1. — P. 29-34.
8. SPRINT MIND Investigators for the SPRINT Research Group. Williamson J.D., Pajewski N.M., et al. Effect of intensive vs standard blood pressure control on probable dementia: a randomized clinical trial // JAMA. — 2019. — 321. — P. 553-561.
9. Staessen J.A., Gasowski J., Wang J.G. et al. Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials // Lancet. — 2000. — Vol. 355 (9207). — P. 865-872.
10. Beckett N.S., Peters R., Fletcher A.E. et al. HYVET Study Group. Treatment of hypertension in patients 80 years of age or older // N. Engl. J. Med. — 2008. — Vol. 358 (18). — P. 1887-1898.
11. SPRINT Research Group. Wright J.T., Williamson J.D., Whelton P.K., Snyder J.K., Sink K.M., Rocco M.V., Reboussin D.M., Rahman M., Oparil S., Lewis C.E., Kimmel P.L., Johnson K.C., Goff D.C., Fine L.J., Cutler J.A., Cushman W.C., Cheung A.K., Ambrosius WT. A Randomized Trial of Intensive versus Standard Blood-Pressure Control // N. Engl. J. Med. — 2015 Nov. 26. — Vol. 373 (22). — P. 2103-2016.
12. Whelton P.K., Carey R.M., Aronow W.S. et al. ACC/AHA/AAPA/ABC/ACPM/AGS /APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines // Hypertension. — 2018. — Vol. 71 (6). — P. 13-115.
13. Williams B., Mancia G., Spiering W. et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension // Eur. Heart. J. — 2018. — Vol. 39 (33). — P. 3021-3104.
14. Divisón-Garrote J.A., Ruilope L.M., de la Sierra A. et al. Magnitude of hypotension based on office and ambulatory blood pressure monitoring: Results from a cohort of 5066 treated hypertensive patients aged 80 years and older // J. Am. Med. Dir. Assoc. — 2017. — Vol. 18. — P. 452.
15. Pastor-Barriuso R., Banegas J.R., Damián J. et al. Systolic blood pressure, diastolic blood pressure, and pulse pressure: An evaluation of their joint effect on mortality // Ann. Intern. Med. — 2003. — Vol. 139. — P. 731-739.