Statins in stroke prevention
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Keywords

atherothrombotic ischemic stroke, simvastatin.

How to Cite

Kuznetsov, V., Romaniuk, T., & Shevchenko, L. (2020). Statins in stroke prevention. The Journal of Neuroscience, 8(1-2), 16-24. Retrieved from https://neuroscience.com.ua/index.php/journal/article/view/225

Abstract

The article presents the results of a comprehensive analysis of the effect of simvastatin (at a dose of 20 mg per day) on the functional state of the brain of patients with atherothrombotic ischemic stroke. In patients with ischemic stroke, simvastatin causes vasoactive effect (increases systolic blood flow velocity and decreases peripheral resistance in some vessels of carotid and vertebrobasilar systems), antiatherogenic action (reduces the size of the intima, reduces the frequency of atherosclerotic plaques, lowers cholesterol, triglycerides, LDL). In patients with atherothrombotic ischemic stroke, simvastatin causes a positive reorganization of the bioelectric activity of the brain (increases the frequency of alpha rhythm and reduces the power in the range of slow rhythms), which is more pronounced in patients with localization of the ischemic lesion in the left hemisphere. Complex positive influence of simvastatin on a cerebral hemodynamics, bioelectric activity of brain, lipid metabolism for patients with atherothrombotic ischemic stroke, grounds to recommend application of simvastatin not only for the secondary prevention of stroke but also for the correction of the functional state of CNS for patients with a stroke in the period of rehabilitation.

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