Possibilities to improve the cognitive function of patients with arterial hypertension
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Keywords

arterial hypertension, hypertensive disease, cognitive functions, antihypertensive therapy, choline alfoscerate.

How to Cite

Mishchenko , L. (2020). Possibilities to improve the cognitive function of patients with arterial hypertension. The Journal of Neuroscience, 8(3-4), 10-15. Retrieved from https://neuroscience.com.ua/index.php/journal/article/view/350

Abstract

The article provides research results of possibilities to increase cognitive patients’ function with arterial hypertension through proving clinical effectiveness and evaluation of tolerability of choline alfoscerate with patients with hypertensive disease and cognitive function disorders. It was proven that cognitive disorders of patients with hypertensive disease appear with defect cognitive domains such as perception, attention, verbal processing speed, and spaced repetition, controlling brain function. The addition of choline alfoscerate to antihypertensive therapy improves the cognitive function of patients with the hypertonic disease and cognitive disorders.

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References

1. Dementia: number of people affected to triple in next 30 years. World Health Organization [website]; 2017 (http:// www.who.int/mediacentre/news/
releases/2017/dementia-triple-affected/en/, accessed 17 April 2018).
2. Launer L.J., Masaki K., Petrovitch H., Foley D., Havlik R.J. The association between midlife blood pressure levels and late-life cognitive function. The Honolulu-Asia Aging Study // JAMA. — 1995. — Vol. 274 (23). — P. 1846-51.
3. Whitmer R.A., Sidney S., Selby J., Johnston S.C., Yaffe K. Midlife cardiovascular risk factors and risk of dementia in late life // Neurology. — 2005. — Vol. 64 (2). —
P. 277-81.
4. Qiu C., Winblad B., Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia // Lancet Neurol. — 2005. — Vol. 4 (8). — P. 487-99.
5. Busse A., Hensel A., Gühne U., Angermeyer M.C., Riedel-Heller S.G. Mild cognitive impairment: long-term course of four clinical subtypes // Neurology. — 2006 Dec 26. — Vol. 67 (12). — P. 2176-85.
6. Oveisgharan S., Hachinski V. Hypertension, executive dysfunction, and progression to dementia: the canadian study of health and aging // Arch. Neurol. — 2010. — Vol. 67 (2). — P. 187-92.
7. Prince M.J., Bird A.S., Blizard R.A., Mann A.H. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of
the Medical Research Council’s trial of hypertension in older adults // BMJ. — 1996 Mar 30. — Vol. 312 (7034). — P. 801-5.
8. Lithell H., Hansson L., Skoog I., Elmfeldt D., Hofman A., Olofsson B., Trenkwalder P., Zanchetti A.; SCOPE Study Group. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized doubleblind intervention trial // J. Hypertens. — 2003 May. — Vol. 21 (5). — P. 875-86.
9. Forette F., Seux M.L., Staessen J.A., et al. The prevention of dementia with antihypertensive treatment. New evidence from the Systolic Hypertension in Europe
(SYST-EUR) study // Arch. Intern. Med. — 2002. — Vol. 162. — P. 2046-52.
10. Tzourio C., Anderson C., Chapman N., et al. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline
in patients with cerebrovascular disease // Arch. Intern. Med. — 2003. — Vol. 163. — P. 1069-75.
11. Godin O., Tzourio C., Maillard P., Mazoyer B., Dufouil C. Antihypertensive treatment and change in blood pressure are associated with the progression of
white matter lesion volumes: the Three-City (3C)-Dijon Magnetic Resonance Imaging Study // Circulation. — 2011. — Vol. 123. — P. 266-273.
12. The SPRINT MIND Investigators for the SPRINT Research Group. Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia. A Randomized
Clinical Trial // JAMA. — 2019. — Vol. 321 (6). — P. 553- 561.
13. Skoog I., Lernfelt B., Landahl S., Palmertz B., Andreasson L.A., Nilsson L., et al. 15-year longitudinal study of blood pressure and dementia // Lancet. — 1996. — Vol. 347 (9009). — P. 1141-5.
14. Molander L., Gustafson Y., Lovheim H. Longitudinal associations between blood pressure and dementia in the very old // Dement. Geriatr. Cogn. Disord. — 2010. — Vol. 30 (3). — P. 269-76.
15. Terry A.V., Buccafusco J.J. The cholinergic hypothesis of age and Alzheimer’s disease-related cognitive deficits: recent challenges and their implications for novel drug development // J. Pharmacol. Exp. Ther. — 2003. — Vol. 306. — P. 821-827.