Uric acid and dementia: a pathogenic factor or marker of cognitive health?


hyperuricemia, uric acid, cognitive impairment, dementia, Parkinson’s disease, Alzheimer’s disease, neurodegenerative diseases, risk factor.

How to Cite

Golovach , I., & Yehudina , Y. (2019). Uric acid and dementia: a pathogenic factor or marker of cognitive health?. The Journal of Neuroscience, 7(2), 43-53. Retrieved from https://neuroscience.com.ua/index.php/journal/article/view/6


In epidemiological studies, hyperuricemia was recognized as an independent risk factor for the development of cardiovascular diseases. However, uric acid (UA) can have a positive effect due to its antioxidant properties, which may be particularly relevant in the context of the development of neurodegenerative diseases. In this paper, we critically revise recent data on the relationship between serum UA levels and cognitive functions in the elderly, with emphasis on etiological factors for cognitive impairment, such as Alzheimer’s disease, Parkinson’s disease and vascular dementia, and on the relationship between UA, dementia and diet. Despite the high heterogeneity in existing studies, due to the different characteristics of the studied populations and heterogeneous methods for assessing cognitive dysfunction, it can be concluded that serum UA can modulate cognitive function in various ways according to the dementia etiology. Current research does show that UA can have a neuroprotective effect in Alzheimer’s and Parkinson’s disease, and hypouricemia is a risk factor for faster progression of neurodegenerative diseases and to be a possible marker of malnutrition in these patients. However, high levels of serum UA adversely affect the course of the disease in vascular dementia. Further studies are needed to clarify the physiopathological role of UA in various types of dementia and its clinical and prognostic significance.



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